Centro-Occidente
 
(Fecha 18)
2 - 3Vendaval vs AD Inter SS |
 
(Fecha 18)
1 - 1San Pablo vs CD Titan |
 
(Fecha 18)
2 - 4ADM Juayua vs Destroyer |
 
(Fecha 18)
2 - 1CD Racing Jr vs AD Santa Rosa |
 
(Fecha 18)
2 - 1RA Sonsonate vs CD Once Lobos |
Centro - Oriente
 
(Fecha 18)
3 - 3CD Cacahuatique vs Marte Soyapango |
 
(Fecha 18)
3 - 0Fuerte San Francisco vs CD Gerardo Barrios |
 
(Fecha 18)
2 - 0CD Aspirante vs Topiltzín |
 
(Fecha 18)
0 - 4Vencedor vs Corinto FC |
 
(Fecha 18)
1 - 0CD Dragon vs Ilopango FC |
Tabla de Posiciones
Occidente - Apertura 2021
| Pos | Equipo | J | G | E | P | GF | GC | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Destroyer | 18 | 11 | 4 | 3 | 40 | 26 | 14 | 37 |
| 2 | San Pablo | 18 | 7 | 7 | 4 | 34 | 29 | 5 | 28 |
| 3 | ADM Juayua | 18 | 7 | 6 | 5 | 40 | 30 | 10 | 27 |
| 4 | AD Inter SS | 18 | 7 | 6 | 5 | 32 | 35 | -3 | 27 |
| 5 | CD Titan | 18 | 6 | 7 | 5 | 34 | 27 | 7 | 25 |
| 6 | CD Racing Jr | 18 | 6 | 7 | 5 | 27 | 27 | 0 | 25 |
| 7 | RA Sonsonate | 18 | 6 | 5 | 7 | 30 | 35 | -5 | 23 |
| 8 | Vendaval | 18 | 6 | 2 | 10 | 35 | 40 | -5 | 20 |
| 9 | AD Santa Rosa | 18 | 4 | 4 | 10 | 36 | 46 | -10 | 16 |
| 10 | CD Once Lobos | 18 | 2 | 8 | 8 | 24 | 37 | -13 | 14 |
Oriente - Apertura 2021
| Pos | Equipo | J | G | E | P | GF | GC | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | CD Cacahuatique | 18 | 11 | 5 | 2 | 39 | 22 | 17 | 38 |
| 2 | Marte Soyapango | 18 | 8 | 6 | 4 | 25 | 20 | 5 | 30 |
| 3 | Corinto FC | 18 | 7 | 8 | 3 | 28 | 17 | 11 | 29 |
| 4 | Topiltzín | 18 | 7 | 6 | 5 | 25 | 22 | 3 | 27 |
| 5 | CD Aspirante | 18 | 7 | 5 | 6 | 25 | 19 | 6 | 26 |
| 6 | CD Dragon | 18 | 6 | 3 | 9 | 30 | 32 | -2 | 21 |
| 7 | Fuerte San Francisco | 18 | 5 | 6 | 7 | 18 | 21 | -3 | 21 |
| 8 | Ilopango FC | 18 | 5 | 4 | 9 | 22 | 27 | -5 | 19 |
| 9 | Vencedor | 18 | 4 | 5 | 9 | 21 | 37 | -16 | 17 |
| 10 | CD Gerardo Barrios | 18 | 3 | 6 | 9 | 28 | 44 | -16 | 15 |